منابع مشابه
MAIT Cells Detect and Efficiently Lyse Bacterially-Infected Epithelial Cells
Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility-complex (MHC) class I molecule, MR1. Here we show that MAIT cells display cytotoxic activity towards MR1 overexpressing non-hematopoietic cells ...
متن کاملMAIT cells: new guardians of the liver
The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non-self food and microbial-derived products from the gut. However, where intestinal mucosal defenses are breached or in the presence of a systemic infection, the liver acts as a second 'firewall', because of its enrichment with innate effector cells able to rapidly r...
متن کاملRole of CD1d-restricted NKT cells in microbial immunity.
The discovery that T cells recognize lipid and glycolipid molecules presented by CD1 proteins has greatly expanded the number of potential microbial antigens targeted by the immune system following infection. The ability of CD1d-restricted NKT cells to activate innate and adaptive immune responses has led to the idea that these cells can modulate immunity to infectious agents. In addition, CD1d...
متن کاملThe Rise and Fall of MAIT Cells with Age
To the Editor, We read with interest the article by Novak et al. recently published in the Scandinavian Journal of Immunology and write in support of their data. The authors describe the profound changes with age of peripheral circulating mucosal associated invariant T (MAIT) cells in a cohort of patients whose samples were obtained post-clinical analysis [1]. We conducted a similar study of a ...
متن کاملStepwise Development of MAIT Cells in Mouse and Human
Mucosal-associated invariant T (MAIT) cells display two evolutionarily conserved features: an invariant T cell receptor (TCR)alpha (iTCRalpha) chain and restriction by the nonpolymorphic class Ib major histocompatibility complex (MHC) molecule, MHC-related molecule 1 (MR1). MR1 expression on thymus epithelial cells is not necessary for MAIT cell development but their accumulation in the gut req...
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ژورنال
عنوان ژورنال: Immunology and Cell Biology
سال: 2018
ISSN: 0818-9641
DOI: 10.1111/imcb.12022